The Agreement Se Lund Pdf Download
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The agreement between Ki67, PR and HER2/neu with HG was not satisfactory, with an agreement rate of 62% (Kappa 0.39). In general, the agreement between HG and MS was good, with a proportion of agreement of 85% (Kappa 0.72). However, in the group of tumours expressing Ki67 > 20%, the agreement between HG and MS was only moderate (67%). This finding confirms the findings of Blumensaat et al. [22] and Maisonneuve et al. [12].
Our study shows that the agreement between Ki67, PR and HER2/neu with the gold standard was moderate. This is in accordance with the findings of other studies, although still not satisfactory [12, 22]. It is, however, important to note that our study population is characterised by a large proportion of ER-negative tumours (50%), which might have been an important factor for the low agreement. It has been shown that agreement in the ER-positive case improves with Ki67, compared to the ER-negative case [22].
Also the agreement between Ki67, PR and HER2/neu with MS was moderate. Despite the fact that we included only node-negative tumours in this study, which are defined as a low-risk group, it is noteworthy that the agreement was still moderate, which might have been expected to be poorer.
We also evaluated the relation between Ki67 and the surrogate classification Ki67, PR and HG in a subgroup of tumours with a Ki67 < 20% (11% of the total). The agreement between HG and Ki67, PR and HG was excellent (Kappa 0.73). This finding shows the importance of including Ki67 < 20% in the surrogate decisions. It might also be true in the case of tumours with Ki67 > 20%, and the agreement between HG and Ki67, PR and HG is moderate. It is noteworthy that in this subgroup, the agreement of HG with Ki67, PR and HER2/neu was excellent (Kappa 0.88).
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